The more things Hiroaki Samura writes, the more convinced I am Blade of the Immortal is his least interesting work. He's been writing the final arc of that manga for as long as I've been reading it, so either he was crazy wrong, or they won't let him end it. (I think it and Oh! My Goddess sell more than all the other titles in Afternoon combined, so this would not be surprising.)
But they have begun letting him run two books at the same time. He's done some work for the art porn magazine Erotics F, and now he's doing Halcyon Lunch, a launch title for Afternoon's new spin-off, Good! Afternoon.
He's been, apparently, drawing sketches of this girl since 1997, but largely unconnected to any actual stories. He seems to have vaguely intended it to be some sort of magical girl series, which is pretty far from what he ended up with.
Instead, Hiyosu is an omnivorous prepubescent space alien hanging out with a homeless dude and pot-growing hippie girl. She can and will eat anything, and vomit it back up. But once she vomits things back up, they generally get recombined into hideous monsters.
The presentation is even more dense and meta than Ohikkoshi was; the first chapter alone has a Find the Differences in These Two Panels puzzle and a shot demonstrating the dangers of lazy video game camera programming. A shot of Hiyosu bursting into the bath is handily covered by a postcard soliciting reader comments, and one chapter is riddled with insipid comments from an off-screen character's Twitter account. It is very much the sort of manga filled with lines like, "Oh no! He's imitating Unit-01 while reciting the names of train stations on the Hachinohe line! His mind is gone!" are very much par for the course. The zombie dog is even retconned as the dog from the cover of Jojo's Bizarre Adventure vol 1.
I suspect it will be criticized for lacking any real semblance of a narrative, but I'm predisposed to enjoy books with an insane thing on every other page.